Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. Ghirlanda G1, Oradei A, Manto A, Lippa S, Uccioli L, Caputo S, Greco AV, Littarru GP.
Author information

Abstract

Inhibitors of HMG-CoA reductase are new safe and effective cholesterol-lowering agents. Elevation of alanine-amino transferase (ALT) and aspartate-amino transferase (AST) has been described in a few cases and a myopathy with elevation of creatinine kinase (CK) has been reported rarely. The inhibition of HMG-CoA reductase affects also the biosynthesis of ubiquinone (CoQ10). We studied two groups of five healthy volunteers treated with 20 mg/day of pravastatin (Squibb, Italy) or simvastatin (MSD) for a month. Then we treated 30 hypercholesterolemic patients in a double-blind controlled study with pravastatin, simvastatin (20 mg/day), or placebo for 3 months. At the beginning, and 3 months thereafter we measured plasma total cholesterol, CoQ10, ALT, AST, CK, and other parameters (urea, creatinine, uric acid, total bilirubin, gamma GT, total protein). Significant changes in the healthy volunteer group were detected for total cholesterol and CoQ10 levels, which underwent about a 40% reduction after the treatment. The same extent of reduction, compared with placebo was measured in hypercholesterolemic patients treated with pravastatin or simvastatin. Our data show that the treatment with HMG-CoA reductase inhibitors lowers both total cholesterol and CoQ10 plasma levels in normal volunteers and in hypercholesterolemic patients. CoQ10 is essential for the production of energy and also has antioxidative properties. A diminution of CoQ10 availability may be the cause of membrane alteration with consequent cellular damage.
PMID:
8463436

Study Type : Human Study
Additional Links
Diseases : Drug-Induced Toxicity : CK(562) : AC(83), High Cholesterol : CK(1774) : AC(271), Myopathies : CK(252) : AC(53)
Additional Keywords : Drug-Nutrient Depletion : CK(64) : AC(7), Statin-Coq10 Depletion : CK(36) : AC(5)
Problem Substances : Lovastatin : CK(267) : AC(68), Pravastatin : CK(251) : AC(42), Simvastatin : CK(754) : AC(153), Statin Drugs : CK(4369) : AC(517)
Adverse Pharmacological Actions : Cytotoxic : CK(85) : AC(50)

Here is the link for the study: https://www.ncbi.nlm.nih.gov/pubmed/8463436

Reduction in coq10 levels may result in mitochondrial dysfunction and cellular damage.
This is not good for one’s health and well-being.

My thoughts on this are to improve your health with a better diet, like you can have with a vegetarian diet. The plant-based diet has been shown to reverse heart disease, diabetes and some cancers.

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If you like this information, you may be interested in my award-winning books:
1. Diabetes And Your Diet (Winner, “Best Health Book of the Year, 2017” of the International Book Award

2. How To Be A Healthy Vegetarian (second edition, Winner for “Best Specialty Cookbook of the Year,” 2017, Book Excellence Awards and Winner for Best Diet and Nutrition Book of the Year, 2017, by the Beverly Hills Book Awards!)

3. Raising Healthy Children, It is a cookbook and a health book. It was a double winner this year. It won Best Parenting Book of the Year and Best Family Book of the Year, 2017 in the International Book Awards.
4. Lose Weight, Get Healthy & Never Be On A Diet Again! (Finalist in the International Book Awards)
5. Feeding Tube Recipe For Optimum Health
6. Co-Author of Alive & Cooking; An Easy Guide To Health For You And Your Parents

copyright@nancyaddison2017

The information from Nancy Addison and Organic Healthy Lifestyle LLC is not offered for the diagnosis, cure, mitigation, treatment, or prevention of any disease or disorder nor have any statements herein been evaluated by the Food and Drug Administration (FDA). We strongly encourage you to discuss topics of concern with your health care provider.

Medical Disclaimer: Information provided in this article, book, podcast, website, email, etc. is for informational purposes only. The information is a result of years of practice and experience by Nancy Addison CHC, AADP. However, this information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product label or packaging.

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He never lived to see his grandchildren grow up.

That doesn’t have to be you.

This article tells you how you can easily prevent and even reverse the effects of heart disease.

Heart Health

The Benefits of Being A Vegetarian

Today is Father’s Day.

My father had heart disease. The picture above,  is a picture of him with my daughter and my mother. I miss him.

Heart Disease is the leading cause of death of men in the United States. Over 307, 225 deaths per year of men in the United States, that is 1 in every 4 male deaths. Half of the men who die suddenly have had no previous symptoms. Heart disease kills 1,100 women a day. One in every 4 deaths a year are from heart disease. My own father had a heart attach when I was in college. He survived it, but I don’t think he ever fully recovered. That was a major reason that I changed the way I eat and live. Because of this being Father’s Day, I am going to address heart disease.

I’m a vegetarian and wrote the book, “How To Be A Healthy Vegetarian.”  I have been a vegetarian for over 27 years, because I had a great many family members die of heart disease, strokes and cancer. So, honoring him today, I thought I would discuss this briefly.

Years ago, I took a Cornell University course on the plant-based diet. Dr. T. Colin Campbell, who participated in the China Study and wrote “The China Study” and Dr. Caldwell B. Esselstyn, Jr. M. D. who wrote “Prevent and Reverse Heart Disease” were two of the professors that taught the course.

Dr. T. Colin Campbell as well as Dr. Caldwell B. Esselstyn (a former surgeon, researcher and clinician at the Cleveland Clinic, -known as the number one heart clinic in the world) believes that by changing the diet, heart disease can be completely cured and prevented.  In our class Dr. Esselstyn explained that cardiology has only focused on treating the symptoms and not the cause.

Dr. Esselstyn explained that a plant-based diet with only a minimum of limited/low healthy fats can not only prevent and stop progression of heart disease, but also reverse it. He explained that his scientific studies show with irrefutable scientific evidence that by changing to a plant based diet, heart disease can be prevented and the epidemic eradicated.

His drew evidence in his results testing with his own patients. He taught that despite the treatments the patients had already received, like bypass surgery or angioplasties, 5 of the original group of 17 had been told by their physicians that they would probably only have about a year to live.  Of the group of 17, there had been at least 49 cardiac events leading up to this study.

Dr. Esselstyn’s 20 year clinical study comprised of 17 compliant patients on his plant based/low fat diet program the health improvement was dramatic. The patients cholesterol dropped, their anginia symptoms and blood flow improved dramatically. Within the 12 years, his 17 patients had no further cardiac events. The patients that stuck with the program survived beyond 20 years, free of symptoms. Anglograms taken of the patients showed a widening of the coronary arteries thus, a reversal of the disease. This study showed one of the most profound drop in cholesterol ever documented in a medical study.

So, if you think that heart disease just happens and that there is nothing you can do about it, then try switching to a plant based / low fat diet and see if that would work for you. It is a lot easier than you think. It just takes a new mindset, a few guide-lines, good recipes and a will to do it.

Last year was my 40^th high school reunion. One of my classmates who had heart disease was told by his physician, that if he switched to a plant based diet he would never have to worry about having a heart attack again. He bought my book and has made some changes to move toward a plant-based diet.

I am so happy for him.  Here is what he said about my book, “How To Be A Healthy Vegetarian:“

“Two years ago I had a quadruple bi-pass, and my cardiologist told me that if I changed to a plant based diet, I would never have this problem again. Being from Texas, I grew up on meat and potatoes, and I was not compliant with his advice. I came across Nancy Addison’s book and it made perfect sense to me with the simple and understandable approach. I’m started off dropping all animal meat, including chicken, which has as much unhealthy fat as steak. Within a month I dropped 17 lbs, just doing that. My system is functioning a lot better, I’ve added more fruits and vegetables, and doubled my energy. I haven’t given up seafood, but maybe down the road I will take the next step. Brava Nancy for getting me to take the first step, and helping me create a new, healthier life!!!!!”
– Ben McKinley – Naples, FL

So, in closing, what we eat in life is a choice. If you have heart disease, you may think about how the food you are eating is directly affecting your health.

I think of everyone who receives my newsletter as my dear friend and I love keeping in touch with you and adore hearing from you. Today, I am sending you big hugs and blessings for a healthy, loving heart this February and may you have a wonderful month full of health and love.

For more information on Nancy’s nutrition and health counseling go to : www.organichealthylifestyle.com

To order Nancy’s book on Amazon:  click here!

Please leave a comment and join the conversation!

Everyone would love to hear what you think!

Copyright@nancyaddison2015

More Reviews of Nancy’s book:

 Surprise content!

I am not a vegetarian but I am keenly interested in nutritional health and wellness. I found Nancy’s chapter topics to be generally relevant and she writes directly to her point so well that I am keeping this book handy as a reference for many kinds of wellness questions, including diet and lifestyle recommendations. I would title this book “How To Be Healthy” and recommend it to anyone interested in making healthier life choices- not just choosing vegetables.      by Christopher Sharp , attorney in Dallas, TX

“How To Be A Healthy Vegetarian” is an excellent book. Having had the opportunity to assist and promote health and nutrition with world-class athletes over the last 25 years; it is my opinion that Nancy Addison’s book is a formula for high-level performance in our daily lives. I can’t imagine a more informative book for the person looking to improve their health. The chapter about sugar is the most complete information available. Nancy is an expert in Nutrition, Healthy Cooking, Raw Food, Living a Healthy Lifestyle and making it all work together. What you put on the end of your fork is more powerful medicine than anything you will find at the bottom of a pill bottle.”

by  Gary L. Massad M.D.

-First National Corporate Medical Director and founder of Occupational Health Centers in America. Attending physician to the Iron Man Hawaii; Attending Physician, United States Triathlon Association; Attending Physician United States Tae Kwon Do Association, Attending Physician United States Cycling Federation.

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